LocusZoom.js

Aggregation Tests Demonstration

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This page demonstrates a mechanism for performing custom aggregation tests interactively, in the web browser. The user can compare several different hypotheses, with contextual visualization to help summarize and interpret the results.

Calculation functionality is provided by raremetal.js.

Build your analysis

Specify the phenotype (such as "low density lipoprotein"), mask(s), and type(s) of aggregation test to run, for all genes in a specified plot region. Use CTRL-click to select more than one mask or test.

Select phenotype

Select mask(s)

Select test(s)

References

Feng, S., Liu, D., Zhan, X., Wing, M. K., & Abecasis, G. R. (2014). RAREMETAL: fast and powerful meta-analysis for rare variants. Bioinformatics, 30(19), 2828-2829. (link)
Liu, D. J., Peloso, G. M., Zhan, X., Holmen, O. L., Zawistowski, M., Feng, S. et al. (2014). Meta-analysis of gene-level tests for rare variant association. Nat Genet, 46(2), 200-204. (link)

LocusZoom.js

Aggregation Tests Demonstration

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Build your analysis

Interactive Plot

Table of aggregation test results

Variants in mask

References